West Diagnostic Centre

ANTI - DSDNA Anti ds- DNA is present in 50-70% patients with systemic lupus erythematosus (SLE). The presence of anti ds DNA is one of the diagnostic criteria for SLE. The reactivity of antibodies to dsDNA may fluctuate with SLE disease activity. Increasing reactivity may be associated with flares while a decline or seronegativity may indicate response to treatment or disease remission.-A positive result for double-stranded DNA (dsDNA) IgG antibodies in the appropriate clinical context is suggestive of systemic lupus erythematosus (SLE)-Weak-positive dsDNA IgG antibody results have a low-positive predictive value for SLE-Negative results do not rule out a diagnosis of SLE. Jun 18, 2026